The 76ers shot an extraordinary 64 per cent from behind the three point line with Reddick top-scoring with 28 points, Belinelli 25 points, Saric 20 points and Ilyasova 17 points.
Simmons had 17 points, 14 assists and nine rebounds for the Sixers. Bellinelli and Ilyasova were vital midseason additions for Philadelphia.
Kelly Olynyk scored 26 points off the bench for the sixth-seeded Heat.
Coach Brett Brown said Friday he couldn't even say that Embiid would return in the first round.
The decision to not play Embiid is far from shocking. He recently underwent surgery to fix a broken orbital bone.
No exact timetable was given for his return, but Embiid will wear a protective mask when he returns to the court. Golden State and Philadelphia will look for 2-0 series leads when their playoff matchups resume Monday. As for Simmons, he averaged 15.8 points, 8.2 rebounds and 8.1 assists per game.