Wednesday, 16 January, 2019

Antibiotics increase the risk of kidney stones

Antibiotics assembled to look like kidneys Antibiotics May Raise the Risk for Kidney Stones
Gustavo Carr | 13 May, 2018, 04:43

The adjusted odds ratio (95% confidence interval) was 2.33 (2.19 to 2.48) for sulfas, 1.88 (1.75 to 2.01) for cephalosporins, 1.67 (1.54 to 1.81) for fluoroquinolones, 1.70 (1.55 to 1.88) for nitrofurantoin/methenamine, and 1.27 (1.18 to 1.36) for broad-spectrum penicillins.

A groundbreaking new study is the first to link the use of antibiotics to kidney stones. Young people also seemed to be most susceptible to developing kidney stones after taking these medications, they add.

A study published Thursday in the Journal of the American Society of Nephrology found that taking any of five types of oral antibiotics was associated with a significantly higher risk of developing kidney stones - mineral and salt deposits that form in the kidneys and must be passed through the urinary tract.

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According to Gregory E. Tasian who is a pediatric urologist and the leader of this research, the entire prevalence regarding kidney stones has seen an increase of around 70% in the last 30 years. Around 30 percent of the prescribed antibiotic files are not the right medication according to Tasian.

He says the theory is that antibiotics disrupt healthy bacteria in the intestinal or urinary tract which then leads to the formation of kidney stones.

Tasian says, there is no certified way to reduce the risk of conditions related to antibiotics intake today but there will be a solution very soon. While diet trends, such as more soda and caffeine, and less water are likely factors, the doctor's team chose to look at common medications, like antibiotics, which are prescribed to children much more than adults. Their goal is to develop a bigger and a population-based research that will help people understand the process easily of how the changes in microbiomes in the body effect in the production of kidney stones. Kidney stones are more common in adults than in kids, but more children and teenagers are getting them lately and some doctors at the Children's Hospital of Philadelphia think antibiotics may play a role. In exploratory analyses, the magnitude of associations was greatest for exposure at younger ages (P 0.001) and 3-6 months before index date (P 0.001), with all but broad-spectrum penicillins remaining statistically significant 3-5 years from exposure.