Monday, 27 May, 2019

Biologists have found a gene responsible for impotence

Биологи нашли ген отвечающий за импотенцию What Causes Erectile Dysfunction? It Could Be in Your Genes
Sandy Nunez | 11 October, 2018, 15:30

Identifying the first genetic risk factor for erectile dysfunction is an exciting discovery because it opens the door for investigations into new, genetic-based therapies, said the study's lead author Eric Jorgenson, research scientist at Kaiser Permanente Northern California's Division of Research. His discovery, according to experts, allows to say that sexual dysfunction in men partly is of genetic nature, reports MedikForum.

Men who have the copy of the genetic variant have a 26 percent higher risk of erectile dysfunction (ED) compared to those who do not.

The team studied over a million points in the human genome in a genomic-wide association study, where markers are scanned to identify genetic variations of a disease or trait. Then, the results have been validated by conducting a study among 222,300 men in Britain.

Researchers from health insurance and medical care company Kaiser Permanente studied the genes of almost 37,000 Americans who volunteered their medical records for the study.

Obesity, diabetes and cardiovascular disease all have genetic components and are also linked to erectile dysfunction.

Though the researchers didn't look at women in this study, they suggest that future research might take a look at the SIM1 gene in females as well. The association was replicated in the U.K. Biobank sample, providing strong confirmation of the findings.

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Although researchers have long suspected that erectile dysfunction may be partially caused by genetics, this study pinpoints the exact location, or locus, that may cause the problem.

Erectile dysfunction has been hard to study in part because of the differences in how patients report their symptoms.

The study then identified a biological role for this location in erectile dysfunction susceptibility. The genetic variation is located near the SIM1 gene, which helps regulate body weight and erections.

The portion of DNA responsible for the possible development of erectile dysfunction, was discovered near the SIM1 gene, which is involved in brain development.

He noted that about 50 per cent of men do not respond to erectile dysfunction treatments now available.

"Hopefully, this will translate into better treatments and, importantly, prevention approaches for the men and their partners who often suffer silently with this condition", said the co-author Hunter Wessells, chair of urology at the University of Washington School of Medicine.