Inspired by her favorite movie The First Wives Club, the pop superstar was joined by the song's co-writers, Victoria Monét and Tayla Parx.
Grande appeared to have tears in her eyes elsewhere during the performance of what may well be her most personal song to date.
At one point, she climbed on top of a chair and almost fell on her way down. She even took the time to learn some rather tight choreography - which is what caused the near-disaster - with her backing singers.
In a statement Billboard's vice president of content Ross Scarano said: "Ariana Grande is a star on her own terms, never bending to any particular musical trend or path in the industry". Holding hands with my mama.
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She powered through the hard moment, ending her live performance with a big smile.
Many fans think the release was a pre-emptive strike as she prepared for whatever Davidson might say on the first "SNL" back on the air since their highly-publicized breakup.
"I thought we were supposed to exit", She laughed.