Vardy is just one in a growing list of Leicester-absentees, with captain Wes Morgan, £3m summer signing Jonny Evans and Rachid Ghezzal doubtful, whilst Harry Maguire is still out with a knee injury.
Leicester come up against former boss Claudio Ranieri at Craven Cottage on Wednesday and Puel believes he may have to do without the England global. "Rest in peace." The second listed the names of the four other people killed in the helicopter crash just over a month ago.
Leicester are unbeaten in their last four games but only picked up six points over that stretch.
Vardy scored in Leicester's Premier League defeat of Watford on Saturday but has been playing through the pain. How Ranieri's side could do with extending that record on Wednesday night. Leicester bought James Maddison in the summer to replace Riyad Mahrez, who was sold to Manchester City.
"I wanted to come back to the Premier League sooner or later. I want to see good progress after Southampton and Chelsea".
The Italian won a shock title with Leicester in 2016 and Puel knows the qualities Ranieri has.
"We need to be aware and be careful of this team because they play very well".
It was both a moment of individual brilliance and a fantastic team goal. Ahead of their first home game since Vichai's death, Leicester City fans and players also marched from city centre to the stadium in tribute for him.
The Cottagers were competitive against the Blues and you can already see some signs that they are going to be more hard to beat - but you cannot just conjure up drastically different results overnight with the same pool of players.