Friday, 14 December, 2018

Ever Baby Born Following A Uterus Transplant From A Deceased Donor

Doctors hold a baby girl born to a mother who received a uterus from a deceased donor in Brazil. A novel transplantation procedure may help more infertile women become pregnant First baby born via uterus transplanted from dead donor
Gustavo Carr | 05 December, 2018, 19:53

A woman in Brazil has successfully given birth after receiving a womb from a dead donor, the first time such a procedure has been successful.

In this study, recently deceased women who had given consent for organ transplant were screened based on previous ability to give birth, blood type, and a lack of any history of sexual disease.

The baby's birth suggests that more women who suffer from uterine infertility - including those who have undergone hysterectomies for reasons ranging from cancer to endometriosis - may be able to take advantage of the procedure moving forward, says paper co-author Dr. Dani Ejzenberg, who oversaw the case and is a medical faculty member in the division of obstetrics and gynecology at the University of São Paulo. Previous attempts in the Czech Republic, Turkey and the us have failed.

The baby girl was delivered last December by a woman born without a uterus because of a rare syndrome.

Nearly exactly a year after the baby's historic birth, Ejzenberg says she is developing normally and her mother feels "fulfilled".

The breakthrough operation, performed two years ago in Brazil, shows that such transplants are feasible and could help thousands of women unable to have children due to uterine problems, according to a study published Tuesday in The Lancet medical journal.

Experts estimate that infertility affects around 10 to 15 per cent of couples of reproductive age worldwide.

He describing the procedure as a "medical milestone".

The healthy baby girl was born via cesarean section at Hospital das Clínicas, at the University of São Paulo School of Medicine, after her mother underwent a uterine transplant followed by an In vitro fertilization (IVF) pregnancy just seven months later.

The donor was 45 years old and died of bleeding on the brain, caused by a stroke.

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The uterus transplant surgery, a first in Latin America, took more than 10 hours to complete.

Five months after the transplant, the uterus showed no signs of rejection and the recipient was menstruating regularly.

The uterus was removed from the donor and transplanted into the recipient in a surgery that also involved connecting the donor uterus and recipient's veins and arteries, ligament and vaginal canals.

"The increase in the number of centers performing this transplant, standardization of the surgical technique and immunosuppressive therapy can facilitate access to this new modality of treatment", he says.

"The numbers of people willing and committed to donate organs upon their own deaths are far larger than those of live donors, offering a much wider potential donor population". Fifteen were fertilised, with 8 resulting in embryos that were subsequently preserved for later implantation. No complications were reported other than a kidney infection at 32 weeks that was treated with antibiotics.

The whole field of uterus transplantation is in its early days.

Hospital staff pictured with the healthy baby.

Dr Srdjan Saso, from Imperial College London, said the results were "extremely exciting".

Richard Kennedy, president of the International Federation of Fertility Societies, also welcomed the announcement but sounded a note of caution.

Dr Falcone said the fact that the transplant was successful after the uterus was preserved in ice for almost eight hours demonstrated how resilient the uterus is.