Wednesday, 24 July, 2019

Novel pill could replace injections to deliver insulin: Study | #99293

Pill Could Replace Insulin Injection for Patients with Diabetes Pill inspired by leopard tortoise could replace diabetic injections
Gustavo Carr | 09 February, 2019, 22:11

Concerning the measurement of a blueberry, the capsule comprises a small needle fabricated from compressed insulin, which is injected after the tablet reaches the abdomen.

That's why insulin - a hormone that helps regulate blood sugar - has to be delivered by injection. Additionally, they demonstrated that the gadget would be tailored to ship different protein medicine.

MIT-led research team has developed a drug capsule that could be used to deliver oral doses of insulin. The tip of the needle is made of 100% compressed, freeze-dried insulin. The shaft of the needle, which doesn't enter the abdomen wall, is produced from one other biodegradable materials.

Next, they needed a trigger for the needle, which is controlled by a disc made of sugar that holds in place a spring. The sugar dissolves when it hits gastric juice, which releases the spring and injects the insulin into the stomach lining.

The researchers say patients won't feel any pain from the injection as the stomach wall has no pain receptors.

When the device reaches the stomach, the capsule reorients itself and injects the insulin into the lining of the stomach. And for long time researchers have pursued a way to orally control insulin.

Pill inspired by leopard tortoise could replace diabetic injections
End to insulin shots? Diabetes patients could take pill containing tiny needles

The team, from Brigham and Women's Hospital and the Massachusetts Institute of Technology, says this localized approach is more pleasant to take, easier to carry around and less expensive than traditional injections. The scientists used computer modeling to design their own version of a self-righting tortoise shell, creating a capsule that can orientate itself correctly, even in the stomach.

Scientists at the Brigham and Women's Hospital in Boston designed this pill, which consists of a biodegradable capsule the size of a chickpea containing an insulin microneedle, according to a press release from the USA center. Video credit: Diana Saville " If a person were to move around or the stomach were to growl, the device would not move from its preferred orientation", said Giovanni Traverso, also senior study author.

Once the contents from the capsule are released, it passes through the digestive system without any side effects. "Our results are encouraging and justify further evaluation of this technique for the oral delivery of insulin and other drugs", said Traverso.

In tests in pigs, the researchers showed that they could successfully deliver up to 300 micrograms of insulin.

The researchers describe the capsule as "about the size of a pea" and made from biodegradable polymer and bits of stainless steel.

Other authors of this study include Alex Abramson, Ester Caffarel-Salvador, Minsoo Khang, David Dellal, David Silverstein, Yuan Gao, Morten Revsgaard Frederiksen, Andreas Vegge, František Hubálek, Jorrit J. Water, Anders V. Friderichsen, Johannes Fels, Rikke Kaae Kirk, Cody Cleveland, Joy Collins, Siddartha Tamang, Alison Hayward, Tomas Landh, Stephen T. Buckley, Niclas Roxhed, and Ulrik Rahbek. They are presently working with working with pharmaceutical company Novo Nordisk to develop SOMA.

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