And although United did not manage a shot on target -they have scored just one goal at home in five Champions League games this season - Pogba insists they have nothing to fear next week.
"Maybe the future might have been worrying him and that's part of the reason he's injured", said Solskjaer.
"Pogba is compatible with any team because he's a great player", Casemiro explained at a Q&A hosted by Nordic Life.
Pellegrini has admitted that West Ham will need to add Nasri to their considerable injury list. I'm not sure if he's going be available for tomorrow.
Solskjaer has plenty of other attacking options at his disposal for a home date with West Ham.
However, the former Sporting man admits he is looking forward to the challenges and believes the season run-in will be "fun".
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Put to Solskjaer that Pogba's statistics have tailed off dramatically, the United boss said: "I think he has made a difference for us in a few games, so has Romelu (Lukaku), so has Marcus (Rashford)".
"We've had Antonio (Valencia), he's going; we've had Ashley (Young); we've had Paul (Pogba), we've had David (de Gea); Chris (Smalling) has been captain, so there are players here who can be captain on the pitch".
"There will be a couple of changes". "But we've let him focus on his fitness".
While planning to shuffle his pack once more, Solskjaer has a number of players unavailable to him. "He's very positive, always helping and always giving advice". He trained individually yesterday.
"We don't have full-backs this week".
United are in sixth place in the Premier League, three points outside the top four, having lost four out of five matches in all competitions since their remarkable victory over PSG in Paris to reach the Champions League quarter-finals.
Barcelona are famed for their ball retention and United face playing much of the game without the ball.