Gurley is listed as doubtful for the game with a quad injury after being held out of practice throughout the week, not a telling sign he'll play Sunday.
"I think we just want to take it a day at a time", McVay said of the Rams' approach with Gurley.
Gurley has rushed for 270 yards and five touchdowns on 64 carries five games into the season.
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Though he has been healthy for all five games this season, Gurley has seen his workload cut dramatically thus far in 2019 relative to 2018.
This was especially demoralizing because the Rams, defending NFC West champions in the midst of a season that'd net another division title and end with a loss in the Super Bowl, were the standard.
This comes with Los Angeles set to take on a 49ers defense that ranks fifth against the run and boasts the No. 2 overall unit in the NFL. LA will likely be without running back Todd Gurley, and cornerback Aqib Talib has been officially ruled out.