He died at a hospital after being reportedly admitted on Thursday following his illness.
Gopalnath was not just a celebrated name in the field of music but he was also the recipient of many coveted awards including a Padma Shri.
Some of his most memorable performances were held at global musical conventions such as the Jazz Festival in Prague, Berlin Jazz Festival, worldwide Cervantino Festival in Mexico, and the Music Hall Festival in Paris.
He is survived by his wife and two sons.
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He had performed the saxophone for Tamil movie "Duet" helmed by late director Okay Balachander with musical rating by A R Rahman, popularising the in any other case lesser recognized instrument among the many individuals in Tamil Nadu.
Gopalnath's death an irreparable loss to the music world: Condoling his death, Karnataka Chief Minister B S Yediyurappa tweeted: 'Kadri Gopalnath's death is an irreparable loss to the music world.
Gopalnath was born in 1950, in Mittakere, Sajeepa Mooda village of Dakshina Kannada.
He learnt Nagaswara at an early age from his father Taniyappa who was a well-known artiste. Gopalnath learnt music from veteran musician T V Gopalakrishnan. He presented his first concert on the All India Radio in 1978. "In his death the world of music has lost a great musician", Yediyurappa said in his message. The funeral will be held on Saturday after his elder son Guruprasad who is working in Kuwait reaches here.
Gopalnath's body will be kept at the town hall for the people to pay their last respects, sources said.