Local police said on Twitter that several roads around the crash site were closed and emergency services were on site. The pilot was able to eject to safety.
The last American military crash in Germany dates back to 2015, when one of the Spangdahlem base's F-16 fighters went down in northern Bavaria. The cause of the September 30 accident remains under investigation. She had no immediate details about the cause of the crash.
Less than a week later, a helicopter pilot died when his aircraft crashed near an army training centre.
Spangdahlem is home to the 52d USAF Fighter Wing which maintains, deploys and employs 24 Lockheed Martin Block 50 F-16CM/DMs.