In the absence of Stafford, whose consecutive starts streak was the sixth longest in National Football League history, the 3-4-1 Lions will be led by former San Francisco 49ers sixth-rounder Jeff Driskel, 26, who'll make make his sixth career start but first for Detroit.
The 31-year-old Stafford had been listed as questionable. The pain intensified through the 2019 season to the point where Stafford was told he should not play.
Below is all you need to know about Stafford's injury, including a timeline of his injury updates and when the Lions might get him back in the lineup.
Detroit Lions quarterback Matthew Stafford has been ruled out for their game at Chicago because of hip and back issues, stopping his streak of 136 consecutive starts. Before his injury, Stafford was maintaining career-highs in passer rating (106.0) and QBR (73.1) this season. It dates back to the 2018 season, where he reportedly played through breaks - all while not missing a game.
Doing his best to try and shift the narrative from those who are negative about him, Stafford has been on a tear so far this season, putting up more touchdowns than interceptions while also going well over 1,000 yards already on the young season. In Week 4, versus the Kansas City Chiefs, he was questionable to play up until kickoff.
Stafford had been playing through pain in his back all season thanks to an injury that reportedly bothered him past year, too.